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PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzyma tic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically Numero articolo: BIOV3174-100 Unità di misura: 100 MCG Imballaggio: Vial 410,00 CHF 410.0 CHF Tempo di consegna attuale su richiesta	PUMA (p53 upregulated modulator of apoptosis) is one of the pro-apoptotic Bcl-2 family members which are also transcriptional target s of p53. PUMA gene encodes two BH3 domain-containing proteins termed PUMA-α and PUMA-β. PUMA proteins bind Numero articolo: BIOV3339-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	BLK, a BH3-containing protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. Numero articolo: BIOV3175-100 Unità di misura: 100 MCG Imballaggio: Vial 360,00 CHF 360.0 CHF Tempo di consegna attuale su richiesta	Paxillin is one of the key components of integrin signaling. Tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization. Paxillin is phosphorylated by another focal adhesion component, focal adhesion Numero articolo: BIOV3448-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta
Bcl-6 encodes a protein of 706 amino acids with a predicted molecular weight of 79 kDa. The Bcl-6 protein has homology with zinc fin ger transcription factors. However, little is known about its functions. Numero articolo: BIOV3408-100 Unità di misura: 100 MCG Imballaggio: Vial 354,00 CHF 354.0 CHF Tempo di consegna attuale su richiesta	Members of the Bcl-2 family of proteins interact to regulate programmed cell death, or apoptosis. Various homodimers and heterodimer s formed by proteins in this family can either promote or inhibit apoptosis. Numero articolo: BIOV3176-100 Unità di misura: 100 MCG Imballaggio: Vial 360,00 CHF 360.0 CHF Tempo di consegna attuale su richiesta	PDK1 (Phosphoinositide-dependent protein kinase 1) plays an important role in cell signaling pathways and is involved in regulation of a wide variety of processes, including cell proliferation, differentiation and apoptosis. Numero articolo: BIOV3449-100 Unità di misura: 100 MCG Imballaggio: Vial 322,00 CHF 322.0 CHF Tempo di consegna attuale su richiesta	The synaptotagmins are integral membrane proteins of synaptic vesicles thoμght to serve as Ca (2+) sensors in the process of vesicul ar trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter Numero articolo: BIOV3177-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta
p53DINP1 (p53-dependent damage-inducible nuclear protein 1) encodes two proteins termed p53DINP1-α (27 kDa) and p53DINP1-β (18 kDa). p53DINP1 may regulate p53-dependent apoptosis throμgh phosphorylation at Ser46 and induction of p53AIP1. p5 Numero articolo: BIOV3340-100 Unità di misura: 100 MCG Imballaggio: Vial 322,00 CHF 322.0 CHF Tempo di consegna attuale su richiesta	Caspase-9 is one of the most important caspases among the caspase family members. Upon induction of apoptosis, cytochrome c released from mitochondria associates with procaspase-9/Apaf-1. Numero articolo: BIOV3409-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	HADH (Hydroxyacyl-Coenzyme A dehydrogenase) is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids , alcohols, and steroids. 3-hydroxyacyl-CoA dehydrogenase type II (HADH2) is a member of the short-chain deh Numero articolo: BIOV3246-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	Members of Oct family of transcription factors specifically interact with Octamer motif ATGCAAAT, a regulatory element important for tissue- and cell-specific transcription as well as for transcription of a number of housekeeping genes. All Numero articolo: BIOV3342-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta
PKC (Protein kinase C) is a calcium-dependent and phospholipid-dependent enzyme that is activated in vivo by the lipid diacylglycero l. PKC has been shown to be involved in signal transduction and various aspects of neoplastic transformation Numero articolo: BIOV3450-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	CD40, also known as bp50 or CDW40, is a type I membrane protein found on the surface of B cells and primary carcinomas. It belongs t o the TNF-R family. CD40 serves as the receptor for CD40 ligand (CD40L Numero articolo: BIOV3178-100 Unità di misura: 100 MCG Imballaggio: Vial 373,00 CHF 373.0 CHF Tempo di consegna attuale su richiesta	PKC (Protein kinase C) is a calcium-dependent and phospholipid-dependent enzyme that is activated in vivo by the lipid diacylglycero l. PKC has been shown to be involved in signal transduction and various aspects of neoplastic transformation Numero articolo: BIOV3451-100 Unità di misura: 100 MCG Imballaggio: Vial 410,00 CHF 410.0 CHF Tempo di consegna attuale su richiesta	Human p21-GTPase-activated protein kinase 1 (PAK1) is a functional homolog of STE20 of Saccharomyces cerevisiae. PAK1 is a downstrea m effector of the Rho-family small GTPases Rac and Cdc42. A serine/threonine kinase Numero articolo: BIOV3248-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta
PKGs are cyclic GMP-dependent protein kinases (also designed cGKs) that are classified into two types, PKGI and PKGII. Studies have shown that cGKs and cyclic AMP-dependent kinases (cAKs) are highly homologous protein kinase families Numero articolo: BIOV3452-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in pa ired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheim Numero articolo: BIOV3453-100 Unità di misura: 100 4G Imballaggio: Vial 455,00 CHF 455.0 CHF Tempo di consegna attuale su richiesta	The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix compon ents, including collagen, gelatin, fibronectin, laminin and proteoglycan. Numero articolo: BIOV3533-100 Unità di misura: 100 MCG Imballaggio: Vial 398,00 CHF 398.0 CHF Tempo di consegna attuale su richiesta	Chemokines play an important role in inflammation and are critical for the recruitment of effector immune cells to sites of infectio n. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine rece Numero articolo: BIOV3414-100 Unità di misura: 100 MCG Imballaggio: Vial 354,00 CHF 354.0 CHF Tempo di consegna attuale su richiesta

VWR / Merck Prodotti chimici