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Receptor interacting protein including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the de ath receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. Numero articolo: BIOV3293-100 Unità di misura: 100 MCG Imballaggio: Vial 354,00 CHF 354.0 CHF Tempo di consegna attuale su richiesta	Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are highly conserved proteins and have importa nt roles in the regulation of metabolism, inflammation, cellular survival growth and differentiation. Numero articolo: BIOV3224-100 Unità di misura: 100 MCG Imballaggio: Vial 322,00 CHF 322.0 CHF Tempo di consegna attuale su richiesta	In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an a llosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step Numero articolo: BIOV3144-100 Unità di misura: 100 MCG Imballaggio: Vial 410,00 CHF 410.0 CHF Tempo di consegna attuale su richiesta	Calreticulin is a calcium binding protein found in abundance in the endoplasmic reticulum and the sarcoplasmic reticulum. Like many other ER proteins, it has the conserved ER retention KDEL (Lys-Asp-Glu-Leu) sequence at its C-terminus. Numero articolo: BIOV3076-100 Unità di misura: 100 MCG Imballaggio: Vial 391,00 CHF 391.0 CHF Tempo di consegna attuale su richiesta
PID/MTA2, also termed MTA1-L1, is a novel molecule that has been found to be involved in p53 pathway. PID/MTA2 modulates the enzymat ic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deac Numero articolo: BIOV3294-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	The Storkhead box protein 2 (STOX2) is a winged-helix domain containing transcription factor. STOX2 has been sμggested to be part of a molecular profile unique to stem cells and may play a role in the differentiation of stem cells. Numero articolo: BIOV3382-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an a llosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step Numero articolo: BIOV3145-100 Unità di misura: 100 MCG Imballaggio: Vial 410,00 CHF 410.0 CHF Tempo di consegna attuale su richiesta	Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an accept or amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal Numero articolo: BIOV3146-100 Unità di misura: 100 MCG Imballaggio: Vial 410,00 CHF 410.0 CHF Tempo di consegna attuale su richiesta
Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/c aspase-9 pathway. Smac/DIABLO binds to IAPs (Inhibitor of Apoptosis Proteins) and neutralizes the inhibitor Numero articolo: BIOV3298-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	Signaling lymphocytic activation molecule (SLAM/CD150) is expressed at hematopoietic tissue, such as memory T-cells, as well as at i mmature thymocytes. It has high-affinity self-ligand ability Numero articolo: BIOV3226-200 Unità di misura: 200 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	CaMKII is a member of calcium/calmodulin-activated kinase, functioning in neural synaptic stimulation and T-cell receptor signaling. CaMKII has catalytic and regulatory domains. The binding of Ca++/calmodulin to its regulatory domain releas Numero articolo: BIOV3383-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	Cytochrome P450 is mainly found in liver, and can metabolize a wide range of compounds such as organic solvents, acetaminophen, dime thylnitrosoamine and aliphatic alcohol, which have certain toxicological effects in humans. Numero articolo: BIOV3084R-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta
D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeleytal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block thr Numero articolo: BIOV3385-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	Profilin is a protein which maintains and shapes cytoskeleton by binding to actin. Profilin 1 has function in breast cancer cell mot ility, radial migration and glial cell adhesion. Numero articolo: BIOV3306-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	Elk-1 is a transcription factor that binds the serum response element (SRE) and mediates gene activity in response to serum and grow th factors. Elk-1 is phosphorylated by MAP kinase pathways and appears to be a direct target of activated MA Numero articolo: BIOV3387-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	Short/branched chain acyl-CoA dehydrogenase(ACADSB) belongs to the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydr ogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. Numero articolo: BIOV3150-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta
NAIP (neuronal apoptosis inhibitor protein) is a member of the IAPs (inhibitor of apoptosis proteins) that function in cell death pa thways to inhibit apoptosis. NAIP was discovered based on its association with a neurodegenerative disorder. Numero articolo: BIOV3228-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	The extracellular signal-regulated kinase 1 and 2 (Erk1 and Erk2) are closely related mitogen activated protein (MAP) kinases that a re activated throμgh the extracellular stimulation by many growth factors, mitogens and differentiation prom Numero articolo: BIOV3085R-100 Unità di misura: 100 MCG Imballaggio: Vial 322,00 CHF 322.0 CHF Tempo di consegna attuale su richiesta	Heat shock proteins (HSPs) are ubiquitously expressed in all organisms. A major function of HSP90 and other HSPs is to act as molecu lar chaperones. HSP90 forms a complex with glucocorticoid receptor (GR), rendering the non ligand-bound rece Numero articolo: BIOV3389-100 Unità di misura: 100 MCG Imballaggio: Vial 354,00 CHF 354.0 CHF Tempo di consegna attuale su richiesta	Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an accept or amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal tr Numero articolo: BIOV3152-100 Unità di misura: 100 MCG Imballaggio: Vial 410,00 CHF 410.0 CHF Tempo di consegna attuale su richiesta

VWR / Merck Prodotti chimici