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Granzyme B is a 27 kDa serine protease stored in granules of activated cytotoxic T cells and NK cells. Upon target cell contact, gra nzyme B is directionally exocytosed and assisted by perforin, enters the target cell. Item Number: BIOV3073-100 Unit of Measure: 100 MCG Packaging: Vial 373.00 CHF 373.0 CHF Current delivery time on request	VENTX is a member of the Vent family of homeodomain proteins. VENTX may function as a transcriptional repressor and involved in meso dermal patterning and hemapoietic stem cell maintenance. Item Number: BIOV3286-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	TACE (TNF-alpha converting enzyme, ADAM17) is a membrane-bound Metalloprotease from the ADAM (a disintegrin and Metalloprotease) fam ily of proteins. It cleaves 26kDa type II membrane-bound precursor of TNF-a into 17 kDa mature form Item Number: BIOV3222R-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Calpains are cytosolic, calcium-dependent, cysteine proteases that are ubiquitously expressed in mammalian and avian tissues. Calpai n-1 and 2 consist of a common small subunit and a large variable subunit. Item Number: BIOV3372-100 Unit of Measure: 100 4G Packaging: Vial 354.00 CHF 354.0 CHF Current delivery time on request
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apopt osis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavag Item Number: BIOV3140-100 Unit of Measure: 100 MCG Packaging: Vial 486.00 CHF 486.0 CHF Current delivery time on request	PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apopt osis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavag Item Number: BIOV3141-100 Unit of Measure: 100 MCG Packaging: Vial 461.00 CHF 461.0 CHF Current delivery time on request	TFPI is also known as lipoproteinassociated coagulation inhibitor (LACI). TFPI encodes a protease inhibitor that regulates the tiss ue factor (TF)-dependent pathway of blood coagulation. Item Number: BIOV3379-100 Unit of Measure: 100 MCG Packaging: Vial 341.00 CHF 341.0 CHF Current delivery time on request	Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are highly conserved proteins and have importa nt roles in the regulation of metabolism, inflammation, cellular survival growth and differentiation. Item Number: BIOV3224-100 Unit of Measure: 100 MCG Packaging: Vial 322.00 CHF 322.0 CHF Current delivery time on request
In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an a llosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step Item Number: BIOV3144-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	The Storkhead box protein 2 (STOX2) is a winged-helix domain containing transcription factor. STOX2 has been sμggested to be part of a molecular profile unique to stem cells and may play a role in the differentiation of stem cells. Item Number: BIOV3382-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an a llosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step Item Number: BIOV3145-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an accept or amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal Item Number: BIOV3146-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request
Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/c aspase-9 pathway. Smac/DIABLO binds to IAPs (Inhibitor of Apoptosis Proteins) and neutralizes the inhibitor Item Number: BIOV3298-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Cytochrome P450 is mainly found in liver, and can metabolize a wide range of compounds such as organic solvents, acetaminophen, dime thylnitrosoamine and aliphatic alcohol, which have certain toxicological effects in humans. Item Number: BIOV3084R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeleytal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block thr Item Number: BIOV3385-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Elk-1 is a transcription factor that binds the serum response element (SRE) and mediates gene activity in response to serum and grow th factors. Elk-1 is phosphorylated by MAP kinase pathways and appears to be a direct target of activated MA Item Number: BIOV3387-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request
Short/branched chain acyl-CoA dehydrogenase(ACADSB) belongs to the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydr ogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. Item Number: BIOV3150-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Heat shock proteins (HSPs) are ubiquitously expressed in all organisms. A major function of HSP90 and other HSPs is to act as molecu lar chaperones. HSP90 forms a complex with glucocorticoid receptor (GR), rendering the non ligand-bound rece Item Number: BIOV3389-100 Unit of Measure: 100 MCG Packaging: Vial 354.00 CHF 354.0 CHF Current delivery time on request	Protein arginine methylation is a form of post-translational modification that is catalyzed by protein arginine methyltransferases ( PRMTs). PRMT6 catalyzes the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side Item Number: BIOV3086-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative spl icing of the gene for GCK results in three tissue-specific forms of glucokinase, one found in pancreatic isl Item Number: BIOV3154-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request

VWR / Merck Chemicals