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AMIFOSTINE TRIHYDRATE, UoM: 1 * 250 mg Item Number: ACRO463102500 Unit of Measure: 250 MG Packaging: Glass bottle 240.00 CHF 240.0 CHF Current delivery time on request	The JNK pathway is activated by largely distinct stimuli including inflammatory cytokines (such as TNF-α and IL-1), UV light, inhibi tors of protein synthesis and osmotic stress. Activated MEKK1 phosphorylates SEK1 (also known as MKK4) Item Number: BIOV3589-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	ATR (ATM and Rad3 related) is closely related to ATM (Ataxia telangiectasia, mutated) and is a member of the phosphatidylinositol 3 kinase (PI-3) family that is an early sensor of DNA damage. ATR is a serine-threonine kinase Item Number: BIOV3767-100 Unit of Measure: 100 4G Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Mutations within the BRCA1 gene, localized to chromosome 17q, are believed to account for approximately 45% of families with increas ed incidence of both early-onset breast cancer and ovarian cancer. Item Number: BIOV3768-100 Unit of Measure: 100 4G Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
Bloom’s syndrome is an autosomal recessive disorder characterized by pre- and post-natal growth deficiencies, sun sensitivity, immun odeficiency and a predisposition to various cancers. The gene responsible for Bloom’s syndrome, BLM, encodes Item Number: BIOV3769-100 Unit of Measure: 100 4G Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	PROTEINASE KINCLUDE INSERT, UoM: 1 * 1 g, CAS: 39450-01-6 Item Number: ICNA0219398191 Unit of Measure: 1 G Packaging: Bottle 1,670.00 CHF 1670.0 CHF Current delivery time on request	The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix compon ents, including collagen, gelatin, fibronectin, laminin and proteoglycan. Item Number: BIOV3529-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Thromboxane B2 (TXB2) is further metabolized enzymatically to a series of compounds, of which 11-dehydro-TXB2 is the major product f ound both in plasma and urine. The dehydrogenase-catalyzing 11-dehydro-TXB2 formation is tissue bound Item Number: BIOV3700-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
Cytochrome c oxidase (COX) is a 13-subunit complex spanning the inner mitochondrial membrane and responsible for the terminal reduct ion of dioxygen to water in the electron transport chain. Item Number: BIOV3638-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Galectins are a family of soluble β-galactoside-binding animal lectins that modulate cell-to-cell and cell-to-ECM interactions, as w ell as apoptosis. Galectin-3 encodes a 30-35 kDa protein containing a single carbohydrate binding domain Item Number: BIOV3591-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix compon ents, including collagen, gelatin, fibronectin, laminin and proteoglycan. Item Number: BIOV3531R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	The JNK pathway is activated by largely distinct stimuli including inflammatory cytokines (such as TNF-α and IL-1), UV light, inhibi tors of protein synthesis and osmotic stress. Activated MEKK1 phosphorylates SEK1 (also known as MKK4) Item Number: BIOV3701-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
Apoptosis plays an important role in many cellular processes. Dio-1 (Death Inducer-O bliterator-1), a putative transcription factor, has been indicated to function in the onset of apoptosis. Dio-1 expression is upregulated when an apoptosis Item Number: BIOV3592-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	ASH2 (absent, small, or homeotic discs 2) is a subunit of a human Set1-like histone methyltransferase (HMT) complex. The Set-1 like complexes are responsible for mono-, di-, and tri-methylation of histone H3 K4. ASH2 associates with a multi Item Number: BIOV3772-100 Unit of Measure: 100 4G Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Steroid receptor coactivator 3 (SRC3) belongs to the SRC family of proteins that interacts with nuclear receptors to facilitate tran scription. The 3 homologous members of this family are SRC-1 (NCoA-1), SRC-2 (GRIP1, TIF2, or NcoA-2) Item Number: BIOV3773-100 Unit of Measure: 100 4G Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Liver X receptors (LXRs) are oxysterol activated nuclear receptors which are involved in the regulation of genesis and metabolism of cholesterols and bile acids. LXRs form heterodimeric complexes with the retinoic acid receptors (RARs) once Item Number: BIOV3641-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request
CLOZAPINE, UoM: 1 * 1 g, CAS: 5786-21-0 Item Number: ACRO464280010 Unit of Measure: 1 G Packaging: Glass bottle 323.00 CHF 323.0 CHF Current delivery time on request	Extracellular stimuli such as growth factors and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun de pendent transcription. Mutation at Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced sign Item Number: BIOV3702-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	TIF1 Alpha/TRIM24 is a member of a family of proteins that control transcription and chromatin remodeling through their interaction with transcription factors. The family of TIF1s (transcriptional intermediary factor 1) includes TIF1-alpha, Item Number: BIOV3774-100 Unit of Measure: 100 4G Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Due to the various splice variants, the trk proteins exist as variably glycosylated entities with the major forms having molecular w eights of 140-145 kDa, 110 kDa and the unglycosylated form of 80 kDa. Item Number: BIOV3593-100 Unit of Measure: 100 MCG Packaging: Vial 391.00 CHF 391.0 CHF Current delivery time on request

VWR / Merck Chemicals