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Caspase-8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase- 8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that lead Item Number: BIOV3258-100 Unit of Measure: 100 MCG Packaging: Vial 442.00 CHF 442.0 CHF Current delivery time on request	The precursor of cytochrome c, apocytochrome c, is synthesized in the cytoplasm. Upon translocation into mitochondria, cytochrome c acquires a heme moiety required for functionality in the mitochondrial respiration chain. Item Number: BIOV3187-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	Human perforin (cytolysin) is believed to be one of the major effector molecules used by cytotoxic T cells and NK cells to mediate t argeted cell lysis. Perforin expression is constitutive on NK cells, but increases in resting XD8+ cytotoxic Item Number: BIOV3188R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Caspase-8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase- 8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that lead Item Number: BIOV3259-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request
Protein kinase A (PKA) also known as cAMP-dependent protein kinase, is a 40 kDa protein kinase that phosphorylates serine or threoni ne residues in target proteins in response to elevated levels of cAMP. It has been sμggested that the comple Item Number: BIOV3115-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	PARD (partitioning-defective) proteins are important in asymmetric cell division and polarized growth. PARD3 plays a vital role in t he formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases Item Number: BIOV3260-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Calpains are cytosolic, calcium-dependent, cysteine proteases that are ubiquitously expressed in mammalian and avian tissues. Type I calpain requires micromolar amounts of calcium, while type II calpain requires millimolar amounts of calciu Item Number: BIOV3189-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	InSolution GSK-3 Inhibitor XVI CHIR99021 Item Number: 361571-5MG Unit of Measure: 5 MG Packaging: Glass bottle 607.00 CHF 607.0 CHF Current delivery time on request
Death Associated Protein 1 (DAP1) is a 15 kDa protein that functions as a positive mediator of cell death initiated by interferon-ga mma. The DAP1 protein is praline-rich and possesses one SH3 binding motif, as well as several consensus prot Item Number: BIOV3261-100 Unit of Measure: 100 MCG Packaging: Vial 360.00 CHF 360.0 CHF Current delivery time on request	PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apopt osis response of cells. Item Number: BIOV3000-100 Unit of Measure: 100 MCG Packaging: Vial 373.00 CHF 373.0 CHF Current delivery time on request	Human Raf1 is a proto-oncogene-encoded 74 kDa kinase that serves as an upstream activator of Mek1 by phosphorylating Ser-218 and Ser -222 in the MAP kinase kinase (Mek1). It has also been implicated in the phosphorylation and activation Item Number: BIOV3116-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	TCTN2 is a member of the Tectonic protein family. Tectonic proteins are transmembrane proteins that regulate the Hedgehog (Hh)-signa ling pathway. Defects in TCTN2 can lead to Meckel syndrome type 8. This disorder is characterized by a comb Item Number: BIOV3262-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consistin g of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sens Item Number: BIOV3117-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apopt osis response of cells. Item Number: BIOV3002-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	The caspase family of cysteine proteases play a key role in apoptosis. Caspase-3 is the most extensively studied apoptotic protein a mong caspase family members. Item Number: BIOV3004-100 Unit of Measure: 100 MCG Packaging: Vial 391.00 CHF 391.0 CHF Current delivery time on request	TRAIL (TNF-related apoptosis-inducing ligand), a member of the TNF ligand family, is a type II membrane protein and expressed in a v ariety of human tissues. Item Number: BIOV3045-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro Item Number: BIOV3191R-100 Unit of Measure: 100 MCG Packaging: Vial 322.00 CHF 322.0 CHF Current delivery time on request	HNF4A is a nuclear transcription factor which binds DNA as a homodimer. This protein controls the expression of several genes, inclu ding hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hep Item Number: BIOV3119-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	Apoptosis occurs during normal cellular development and involves dramatic changes in cellular structure. Disruption of apoptosis may contribute to cancer as well as many other types of diseases. Item Number: BIOV3048-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Fodrin is a universally expressed membrane-associated cytoskeletal protein consisting of α- and β-subunits. The protein is important for maintaining normal membrane structure and supporting cell surface protein function. α-Fodrin is one of Item Number: BIOV3266-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request

VWR / Merck Chemicals