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The Toll-like receptor (TLR) family in mammalian comprises a family of transmembrane proteins characterized by multiple copies of le ucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Up-to-date Item Number: BIOV3552R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer Item Number: BIOV3475-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	Noxa is a BH3-only member of the Bcl-2 family. Expression of Noxa gene involves direct activation of its promotor by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Item Number: BIOV3665-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Human HDAC7 is composed of 912 amino acid residues. Althoμgh HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, sμggesting nucleo-cytoplasmic shuttling. Item Number: BIOV3607-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request
Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer Item Number: BIOV3476-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	TRYPSIN INHIBITOR(SOYBEAN)-N/H, UoM: 1 * 500 mg, CAS: 9035-81-8 Item Number: ICNA0210111390 Unit of Measure: 500 MG Packaging: Glasflasche für Feststoffe 697.00 CHF 697.0 CHF Current delivery time on request	MLK3 (Mixed lineage kinase 3) is a serine/threonine kinase that has an amino-terminal SH3 domain followed by the kinase domain and t wo leucine zippers, a cdc42/Rac1 binding (CRIB) domain and several other domains/motifs at the carboxy-termi Item Number: BIOV3430-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines. Activation of SEK1 occurs throμgh phosphorylation Item Number: BIOV3478-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request
Mammalian HDAC-8, isolated from human kidney, is a member of the histone deacetylase family. HDAC-8 shares homology with other HDACs in the family, but has different tissue distribution. Item Number: BIOV3608-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	BROMELAIN--N/H, UoM: 1 * 1 kg, CAS: 37189-34-7 Item Number: ICNA0210114291 Unit of Measure: 1 KG Packaging: Glasflasche für Feststoffe 2,170.00 CHF 2170.0 CHF Current delivery time on request	LIM kinases (LIMK1 and LIMK2) are serine/threnine kinases that have two zinc finger motifs, known as LIM motifs in their N-terminal regulatory domain. LIM kinases are involved in actin cytoskeleton regulation throμgh Rho-family GTPases and Item Number: BIOV3433-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	PTEN (phosphatase and tensin homologue deleted on chromosome ten) phosphatase is a tumor suppressor gene implicated in a wide variet y of human cancers. PTEN encodes the 403 amino acid polypeptide originally described as a dual-specificity p Item Number: BIOV3479-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request
The Toll-like receptor (TLR) family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essentia l for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembr Item Number: BIOV3555R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	MAP kinase-activated protein kinase-2 (MAPKAPK-2), also known as p45 hsp27 kinase, is a 45-54 kDa serine-threonine protein kinase. M APKAPK-2 is rapidly phosphorylated and activated in response to stress, cytokines, and chemotactic factors. Item Number: BIOV3434-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	"p38 MAP kinase is the mammalian homologue of the yeast HOG kinase and participates in a Item Number: BIOV3438-100 Unit of Measure: 100 MCG Packaging: Vial 436.00 CHF 436.0 CHF Current delivery time on request	Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been l inked to early onset of Alzheimer’s disease, probably functioning throμgh its associated g-secretase activit Item Number: BIOV3482-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request
HDAC family members have been divided into two classes. Class I of the HDACs comprises four members, HDAC-1, 2, 3, and 8, each of wh ich contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the Item Number: BIOV3609-100 Unit of Measure: 100 MCG Packaging: Vial 379.00 CHF 379.0 CHF Current delivery time on request	The Toll-like receptor (TLR) family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essentia l for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembr Item Number: BIOV3557-100 Unit of Measure: 100 4G Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	JMJD1C is a member of the jumonji (jmj) domain containing gene family of histone demethylases that plays a role in chromatin regulat ion and influences transcriptional activation and suppression. Item Number: BIOV3439-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Rab5 is a 24 kDa GTP-binding protein that is localized to the cytoplasmic side of the plasma membrane, clathrin-coated vesicles, and early endosomes. Rab5 is believed to regulate vesicle fusion throμgh a cycle of GDP/GTP exchange and GTP hy Item Number: BIOV3483-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request

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