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Cathepsin F is a cysteine protease that plays a role in invariant chain processing and major histocompatibility complex class II pep tide loading by microphages. Cathepsin F has the substrate specificity similar to that of cathepsins L and S Item Number: BIOV3371-100 Unit of Measure: 100 4G Packaging: Vial 335.00 CHF 335.0 CHF Aktuelle Lieferfrist auf Anfrage	Deoxyribonuclease I (DNase I) is a Ca2+ and Mg2+ dependent endonuclease. DNase I is synthesized in the pancreas and stored in zymoge n granules. It has been used to reduce the viscosity of cystic fibrosis sputum. Item Number: BIOV3214-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Aktuelle Lieferfrist auf Anfrage	MKK3 is a protein kinase that phosphorylates the p38 MAPK. Phosphorylation by MKK3 occurs on threonine and tyrosine residues and inc reases the activity of p38 to stimulate transcription factors ATF2 and Elk-1. MKK3, together with MKK6, serv Item Number: BIOV3285-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Aktuelle Lieferfrist auf Anfrage	The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cat hepsins B, L, H, K, S, and O. The aspartyl protease class is composed of cathepsins D and E. Item Number: BIOV3370-200 Unit of Measure: 200 4G Packaging: Vial 360.00 CHF 360.0 CHF Aktuelle Lieferfrist auf Anfrage
Granzyme B is a 27 kDa serine protease stored in granules of activated cytotoxic T cells and NK cells. Upon target cell contact, gra nzyme B is directionally exocytosed and assisted by perforin, enters the target cell. Item Number: BIOV3073-100 Unit of Measure: 100 MCG Packaging: Vial 373.00 CHF 373.0 CHF Aktuelle Lieferfrist auf Anfrage	VENTX is a member of the Vent family of homeodomain proteins. VENTX may function as a transcriptional repressor and involved in meso dermal patterning and hemapoietic stem cell maintenance. Item Number: BIOV3286-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Aktuelle Lieferfrist auf Anfrage	TACE (TNF-alpha converting enzyme, ADAM17) is a membrane-bound Metalloprotease from the ADAM (a disintegrin and Metalloprotease) fam ily of proteins. It cleaves 26kDa type II membrane-bound precursor of TNF-a into 17 kDa mature form Item Number: BIOV3222R-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Aktuelle Lieferfrist auf Anfrage	Calpains are cytosolic, calcium-dependent, cysteine proteases that are ubiquitously expressed in mammalian and avian tissues. Calpai n-1 and 2 consist of a common small subunit and a large variable subunit. Item Number: BIOV3372-100 Unit of Measure: 100 4G Packaging: Vial 354.00 CHF 354.0 CHF Aktuelle Lieferfrist auf Anfrage
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apopt osis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavag Item Number: BIOV3140-100 Unit of Measure: 100 MCG Packaging: Vial 486.00 CHF 486.0 CHF Aktuelle Lieferfrist auf Anfrage	PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apopt osis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavag Item Number: BIOV3141-100 Unit of Measure: 100 MCG Packaging: Vial 461.00 CHF 461.0 CHF Aktuelle Lieferfrist auf Anfrage	TFPI is also known as lipoproteinassociated coagulation inhibitor (LACI). TFPI encodes a protease inhibitor that regulates the tiss ue factor (TF)-dependent pathway of blood coagulation. Item Number: BIOV3379-100 Unit of Measure: 100 MCG Packaging: Vial 341.00 CHF 341.0 CHF Aktuelle Lieferfrist auf Anfrage	Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are highly conserved proteins and have importa nt roles in the regulation of metabolism, inflammation, cellular survival growth and differentiation. Item Number: BIOV3224-100 Unit of Measure: 100 MCG Packaging: Vial 322.00 CHF 322.0 CHF Aktuelle Lieferfrist auf Anfrage
In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an a llosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step Item Number: BIOV3144-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Aktuelle Lieferfrist auf Anfrage	The Storkhead box protein 2 (STOX2) is a winged-helix domain containing transcription factor. STOX2 has been sμggested to be part of a molecular profile unique to stem cells and may play a role in the differentiation of stem cells. Item Number: BIOV3382-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Aktuelle Lieferfrist auf Anfrage	In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an a llosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step Item Number: BIOV3145-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Aktuelle Lieferfrist auf Anfrage	Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an accept or amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal Item Number: BIOV3146-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Aktuelle Lieferfrist auf Anfrage
Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/c aspase-9 pathway. Smac/DIABLO binds to IAPs (Inhibitor of Apoptosis Proteins) and neutralizes the inhibitor Item Number: BIOV3298-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Aktuelle Lieferfrist auf Anfrage	Cytochrome P450 is mainly found in liver, and can metabolize a wide range of compounds such as organic solvents, acetaminophen, dime thylnitrosoamine and aliphatic alcohol, which have certain toxicological effects in humans. Item Number: BIOV3084R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Aktuelle Lieferfrist auf Anfrage	D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeleytal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block thr Item Number: BIOV3385-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Aktuelle Lieferfrist auf Anfrage	Elk-1 is a transcription factor that binds the serum response element (SRE) and mediates gene activity in response to serum and grow th factors. Elk-1 is phosphorylated by MAP kinase pathways and appears to be a direct target of activated MA Item Number: BIOV3387-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Aktuelle Lieferfrist auf Anfrage

VWR / Merck Chemicals