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APROTININ, UoM: 1 * 250 mg, CAS: 9087-70-1 Item Number: ICNA0219115883 Unit of Measure: 250 MG Packaging: Glasflasche für Feststoffe 2,210.00 CHF 2210.0 CHF Current delivery time on request	Highly expressed in cancer (Hec1) is a coiled-coil-enriched protein expressed abundantly in the S and M phases of rapidly dividing c ells where it localizes to the kinetochores. Hec1 is involved in spindle checkpoint signaling. Item Number: BIOV3763-100 Unit of Measure: 100 4G Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	XAF-1 binds to XIAP, an inhibitor of caspases-3, -7, -9 and triggers its relocation from the cytosol to the nucleus. Overexpression of XAF-1 results in the neutralization of XIAP’s ability to inhibit cell death. Item Number: BIOV3696-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	KAP-1 (KRAB-Associated Protein 1) is a member of the tripartite motif RBCC/Trim domain family that contains a RING finger domain, B boxes, and an alpha helical coiled coil region. KAP-1 functions as a corepressor by interacting with the KRA Item Number: BIOV3764-100 Unit of Measure: 100 4G Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
NDRG1 is a cytoplasmic protein that is involved in stress responses, hormone responses, cell growth, and differentiation. NDRG1 is o ne of 4 members of the NDRG α/β-hydrolase family. It is classified as a tumor suppressor and heavy metal-res Item Number: BIOV3526-100 Unit of Measure: 100 MCG Packaging: Vial 347.00 CHF 347.0 CHF Current delivery time on request	Cathepsin family of proteases contains several diverse classes of enzymes. The cysteine protease class comprises cathepsin B, H, K, L, O, and S. The aspartyl protease class contains cathepsin D and E. Item Number: BIOV3588-100 Unit of Measure: 100 MCG Packaging: Vial 391.00 CHF 391.0 CHF Current delivery time on request	Cell cycle progression is subject to arrest at the mitotic spindle assembly checkpoint in response to incorrect spindle fiber assemb ly. MAD1 and MAD2 (for mitotic arrest-deficient 1 and 2) are components of the mitotic spindle checkpoint. I Item Number: BIOV3765-100 Unit of Measure: 100 4G Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	PAX genes encode nuclear transcription factors that may function as major controllers of developmental processes in both vertebrates and invertebrates. Mutations in murine PAX genes underlie three natural mouse alleles and several correspon Item Number: BIOV3636R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
Dicer is an RNaseIII-like enzyme which cleaves double-stranded RNA into 21-23 nucleotide (nt) RNAs. These RNAs are referred to as si RNA (short interfering RNA). It is believed to be essential in siRNA-mediated gene suppression. Item Number: BIOV3697-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	ALBUMIN, HUMAN PLASMA--N/H, UoM: 1 * 5 g, CAS: 70024-90-7 Item Number: ICNA0219134905 Unit of Measure: 5 G Packaging: Glasflasche für Feststoffe 2,280.00 CHF 2280.0 CHF Current delivery time on request	NERATINIB, UoM: 1 * 250 mg Item Number: ACRO464702500 Unit of Measure: 250 MG Packaging: Glass bottle 118.00 CHF 118.0 CHF Current delivery time on request	AMIFOSTINE TRIHYDRATE, UoM: 1 * 250 mg Item Number: ACRO463102500 Unit of Measure: 250 MG Packaging: Glass bottle 240.00 CHF 240.0 CHF Current delivery time on request
The JNK pathway is activated by largely distinct stimuli including inflammatory cytokines (such as TNF-α and IL-1), UV light, inhibi tors of protein synthesis and osmotic stress. Activated MEKK1 phosphorylates SEK1 (also known as MKK4) Item Number: BIOV3589-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	ATR (ATM and Rad3 related) is closely related to ATM (Ataxia telangiectasia, mutated) and is a member of the phosphatidylinositol 3 kinase (PI-3) family that is an early sensor of DNA damage. ATR is a serine-threonine kinase Item Number: BIOV3767-100 Unit of Measure: 100 4G Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Mutations within the BRCA1 gene, localized to chromosome 17q, are believed to account for approximately 45% of families with increas ed incidence of both early-onset breast cancer and ovarian cancer. Item Number: BIOV3768-100 Unit of Measure: 100 4G Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Bloom’s syndrome is an autosomal recessive disorder characterized by pre- and post-natal growth deficiencies, sun sensitivity, immun odeficiency and a predisposition to various cancers. The gene responsible for Bloom’s syndrome, BLM, encodes Item Number: BIOV3769-100 Unit of Measure: 100 4G Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request
PROTEINASE KINCLUDE INSERT, UoM: 1 * 1 g, CAS: 39450-01-6 Item Number: ICNA0219398191 Unit of Measure: 1 G Packaging: Bottle 1,670.00 CHF 1670.0 CHF Current delivery time on request	The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix compon ents, including collagen, gelatin, fibronectin, laminin and proteoglycan. Item Number: BIOV3529-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Thromboxane B2 (TXB2) is further metabolized enzymatically to a series of compounds, of which 11-dehydro-TXB2 is the major product f ound both in plasma and urine. The dehydrogenase-catalyzing 11-dehydro-TXB2 formation is tissue bound Item Number: BIOV3700-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Cytochrome c oxidase (COX) is a 13-subunit complex spanning the inner mitochondrial membrane and responsible for the terminal reduct ion of dioxygen to water in the electron transport chain. Item Number: BIOV3638-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request

VWR / Merck Chemicals