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Etk is a member of the Bruton’s tyrosine kinase family. Etk is expressed in a variety of hematopoietic, epithelial and endothelial c ells. It participates in multiple signal transduction pathways. Phosphorylation of tyrosine 566 by Src kinas Item Number: BIOV3398R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic developmen t and in the determination of the cell fate. The protein may act as a transcriptional regulator after formin Item Number: BIOV3168-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	The PAK (p21-activated kinase) family of serine/threonine kinases plays an important role in multiple cellular processes, including cytoskeletal reorganization, MAPK signaling, apoptotic signaling, etc. Several mechanisms that induce PAK ac Item Number: BIOV3444-100 Unit of Measure: 100 MCG Packaging: Vial 328.00 CHF 328.0 CHF Current delivery time on request	Bmf (for Bcl-2-modifying factor) is a novel BH3-only protein recently identified in human and mouse. The BH3 domain in Bmf is requir ed for both binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Item Number: BIOV3334R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
Focal adhesion kinase was identified as a 125 kDa substrate for the intrinsic protein tyrosine kinase activity of Src encoded pp60. The deduced amino acid sequence of FAK p125 has shown it to be a cytoplasmic protein tyrosine kinase Item Number: BIOV3399-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	AMPK2 alpha2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha cataly tic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that moni Item Number: BIOV3169-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	Survivin is a newly described apoptosis inhibitor that is expressed in many human cancers, but undetectable in terminally differenti ated adult tissues. It has been shown that recombinant expression of Survivin counteracts apoptosis of B lym Item Number: BIOV3170-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Endonuclease G (EndoG) is a mitochondrion-specific nuclease that specifically activated by apoptotic stimuli and translocates to the nucleus during apoptosis. In nucleus, EndoG induces nucleosomal fragmentation of DNA independent of caspase Item Number: BIOV3336R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
NORDIHYDROGUAIARETIC ACID, UoM: 1 * 500 mg, CAS: 500-38-9 Item Number: CAYM70300-500 Unit of Measure: 500 MG Packaging: Glass bottle for solids 65.70 CHF 65.7 CHF Current delivery time on request	ILP-2 (for IAP-like protein-2) is a novel member of in the IAP (Inhibitor of Apoptosis) protein family. ILP-2 has high homology to I LP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. Item Number: BIOV3337-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	To date, at least ten members of the Toll family have been identified. TLRs recognize molecular patterns associated with microbial p athogens and induce antimicrobial immune response. TLR3 recognizes double-stranded (ds) RNA Item Number: BIOV3445R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	$Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is localized in the cytosolic fraction of cells as an inactive precur sor. Its active form is generated upon proteolytic cleavage by caspase-8 in the Fas signaling pathway.$ Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is localized in the cytosolic fraction of cells as an inactive precur sor. Its active form is generated upon proteolytic cleavage by caspase-8 in the Fas signaling pathway. Item Number: BIOV3172-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
Five ionomycin-inducible complementary cDNAs, designated PAR1, 2, 3, 4 and 5, have been isolated from the prostate cancer cell line AT-3. Nucleotide sequencing identified PAR1 as the rat homolog of monkeyP-1, PAR2 as the injury-inducible ge Item Number: BIOV3447-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	The TLR (toll-like receptors) family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essenti al for Toll-induced signal transduction. TLR1, as well as the other TLR family members Item Number: BIOV3446-100 Unit of Measure: 100 4G Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Livin is a novel member in the IAP (inhibitor of apoptosis) protein family. Livin contains a single baculoviral IAP repeat (BIR) dom ain and a RING finger domain and has two isoforms termed Livin-α and Livin-β. Transfection of Livin protecte Item Number: BIOV3338-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	MyD88 was identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 recep tor complex in response to IL-1 treatment. Dominant-negative form of MyD88 attenuates IL-1R-mediated NF-B a Item Number: BIOV3244R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
Bcl-3, a proto-oncogene, is believed to be involved in certain human B cell leukemias. It encodes a protein that functions as an IkB -like molecule for native NFkB, but is specific for the p50 subunit of NFkB. Item Number: BIOV3407-100 Unit of Measure: 100 MCG Packaging: Vial 354.00 CHF 354.0 CHF Current delivery time on request	PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzyma tic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically Item Number: BIOV3174-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	PUMA (p53 upregulated modulator of apoptosis) is one of the pro-apoptotic Bcl-2 family members which are also transcriptional target s of p53. PUMA gene encodes two BH3 domain-containing proteins termed PUMA-α and PUMA-β. PUMA proteins bind Item Number: BIOV3339-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	BLK, a BH3-containing protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. Item Number: BIOV3175-100 Unit of Measure: 100 MCG Packaging: Vial 360.00 CHF 360.0 CHF Current delivery time on request

VWR / Merck Chemicals