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Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the m ains two pathways, in which the key apoptotic proteases caspase-8 and caspase-9, respectively, are involved. Numero articolo: BIOV3282-100 Unità di misura: 100 MCG Imballaggio: Vial 354,00 CHF 354.0 CHF Tempo di consegna attuale su richiesta	Cathepsin F is a cysteine protease that plays a role in invariant chain processing and major histocompatibility complex class II pep tide loading by microphages. Cathepsin F has the substrate specificity similar to that of cathepsins L and S Numero articolo: BIOV3371-100 Unità di misura: 100 4G Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	Deoxyribonuclease I (DNase I) is a Ca2+ and Mg2+ dependent endonuclease. DNase I is synthesized in the pancreas and stored in zymoge n granules. It has been used to reduce the viscosity of cystic fibrosis sputum. Numero articolo: BIOV3214-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	Medium-chain acyl-CoA dehydrogenase (MCAD, ACADM) is a homotetramer enzyme that catalyzes the initial step of the mitochondrial fatt y acid beta-oxidation pathway. Numero articolo: BIOV3137-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta
CD40 is a type I membrane protein found on the surface of B cells and primary carcinomas. It belongs to the TNF-R family. CD40 serve s as the receptor for CD40 ligand (CD40L), a cytokine expressed on the cell surface of T cells. Numero articolo: BIOV3072-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. It has also been used as a potential regulator of tumor growth and metastasis. TSP expression is highly regulated by dif Numero articolo: BIOV3283-100 Unità di misura: 100 MCG Imballaggio: Vial 347,00 CHF 347.0 CHF Tempo di consegna attuale su richiesta	Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-3 is synthesized as an inactive pro-enz yme (32 kDa) that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by another Numero articolo: BIOV3138-100 Unità di misura: 100 MCG Imballaggio: Vial 360,00 CHF 360.0 CHF Tempo di consegna attuale su richiesta	MKK3 is a protein kinase that phosphorylates the p38 MAPK. Phosphorylation by MKK3 occurs on threonine and tyrosine residues and inc reases the activity of p38 to stimulate transcription factors ATF2 and Elk-1. MKK3, together with MKK6, serv Numero articolo: BIOV3285-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta
The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cat hepsins B, L, H, K, S, and O. The aspartyl protease class is composed of cathepsins D and E. Numero articolo: BIOV3370-200 Unità di misura: 200 4G Imballaggio: Vial 360,00 CHF 360.0 CHF Tempo di consegna attuale su richiesta	Granzyme B is a 27 kDa serine protease stored in granules of activated cytotoxic T cells and NK cells. Upon target cell contact, gra nzyme B is directionally exocytosed and assisted by perforin, enters the target cell. Numero articolo: BIOV3073-100 Unità di misura: 100 MCG Imballaggio: Vial 373,00 CHF 373.0 CHF Tempo di consegna attuale su richiesta	VENTX is a member of the Vent family of homeodomain proteins. VENTX may function as a transcriptional repressor and involved in meso dermal patterning and hemapoietic stem cell maintenance. Numero articolo: BIOV3286-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	ASC (also called TMS1) is a CARD domain containing protein. ASC induces apoptosis throμgh activation of caspase-9 and inhibiting the survival of human breast cancer cells. Overexpression of ASC/TMS1 induced DNA fragmentation. Numero articolo: BIOV3291-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta
Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and pro grammed cell death. TNF-α is synthesized as a 26K type II membrane-bound precursor Numero articolo: BIOV3222-100 Unità di misura: 100 MCG Imballaggio: Vial 354,00 CHF 354.0 CHF Tempo di consegna attuale su richiesta	TACE (TNF-alpha converting enzyme, ADAM17) is a membrane-bound Metalloprotease from the ADAM (a disintegrin and Metalloprotease) fam ily of proteins. It cleaves 26kDa type II membrane-bound precursor of TNF-a into 17 kDa mature form Numero articolo: BIOV3222R-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	Calpains are cytosolic, calcium-dependent, cysteine proteases that are ubiquitously expressed in mammalian and avian tissues. Calpai n-1 and 2 consist of a common small subunit and a large variable subunit. Numero articolo: BIOV3372-100 Unità di misura: 100 4G Imballaggio: Vial 354,00 CHF 354.0 CHF Tempo di consegna attuale su richiesta	PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apopt osis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavag Numero articolo: BIOV3140-100 Unità di misura: 100 MCG Imballaggio: Vial 486,00 CHF 486.0 CHF Tempo di consegna attuale su richiesta
PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apopt osis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavag Numero articolo: BIOV3141-100 Unità di misura: 100 MCG Imballaggio: Vial 461,00 CHF 461.0 CHF Tempo di consegna attuale su richiesta	TFPI is also known as lipoproteinassociated coagulation inhibitor (LACI). TFPI encodes a protease inhibitor that regulates the tiss ue factor (TF)-dependent pathway of blood coagulation. Numero articolo: BIOV3379-100 Unità di misura: 100 MCG Imballaggio: Vial 341,00 CHF 341.0 CHF Tempo di consegna attuale su richiesta	Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. This gene encod es hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose- Numero articolo: BIOV3143-100 Unità di misura: 100 MCG Imballaggio: Vial 410,00 CHF 410.0 CHF Tempo di consegna attuale su richiesta	Receptor interacting protein including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the de ath receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. Numero articolo: BIOV3293-100 Unità di misura: 100 MCG Imballaggio: Vial 354,00 CHF 354.0 CHF Tempo di consegna attuale su richiesta

VWR / Merck Prodotti chimici