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Endonuclease G (EndoG) is a mitochondrion-specific nuclease that specifically activated by apoptotic stimuli and translocates to the nucleus during apoptosis. In nucleus, EndoG induces nucleosomal fragmentation of DNA independent of caspase Numero articolo: BIOV3336R-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	NORDIHYDROGUAIARETIC ACID Numero articolo: CAYM70300-500 Unità di misura: 500 MG Imballaggio: Glass bottle for solids 65,70 CHF 65.7 CHF Tempo di consegna attuale su richiesta	ILP-2 (for IAP-like protein-2) is a novel member of in the IAP (Inhibitor of Apoptosis) protein family. ILP-2 has high homology to I LP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. Numero articolo: BIOV3337-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	To date, at least ten members of the Toll family have been identified. TLRs recognize molecular patterns associated with microbial p athogens and induce antimicrobial immune response. TLR3 recognizes double-stranded (ds) RNA Numero articolo: BIOV3445R-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta
$Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is localized in the cytosolic fraction of cells as an inactive precur sor. Its active form is generated upon proteolytic cleavage by caspase-8 in the Fas signaling pathway.$ Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is localized in the cytosolic fraction of cells as an inactive precur sor. Its active form is generated upon proteolytic cleavage by caspase-8 in the Fas signaling pathway. Numero articolo: BIOV3172-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	Five ionomycin-inducible complementary cDNAs, designated PAR1, 2, 3, 4 and 5, have been isolated from the prostate cancer cell line AT-3. Nucleotide sequencing identified PAR1 as the rat homolog of monkeyP-1, PAR2 as the injury-inducible ge Numero articolo: BIOV3447-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	The TLR (toll-like receptors) family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essenti al for Toll-induced signal transduction. TLR1, as well as the other TLR family members Numero articolo: BIOV3446-100 Unità di misura: 100 4G Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	Livin is a novel member in the IAP (inhibitor of apoptosis) protein family. Livin contains a single baculoviral IAP repeat (BIR) dom ain and a RING finger domain and has two isoforms termed Livin-α and Livin-β. Transfection of Livin protecte Numero articolo: BIOV3338-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta
MyD88 was identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 recep tor complex in response to IL-1 treatment. Dominant-negative form of MyD88 attenuates IL-1R-mediated NF-B a Numero articolo: BIOV3244R-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta	Bcl-3, a proto-oncogene, is believed to be involved in certain human B cell leukemias. It encodes a protein that functions as an IkB -like molecule for native NFkB, but is specific for the p50 subunit of NFkB. Numero articolo: BIOV3407-100 Unità di misura: 100 MCG Imballaggio: Vial 354,00 CHF 354.0 CHF Tempo di consegna attuale su richiesta	PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzyma tic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically Numero articolo: BIOV3174-100 Unità di misura: 100 MCG Imballaggio: Vial 410,00 CHF 410.0 CHF Tempo di consegna attuale su richiesta	PUMA (p53 upregulated modulator of apoptosis) is one of the pro-apoptotic Bcl-2 family members which are also transcriptional target s of p53. PUMA gene encodes two BH3 domain-containing proteins termed PUMA-α and PUMA-β. PUMA proteins bind Numero articolo: BIOV3339-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta
BLK, a BH3-containing protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. Numero articolo: BIOV3175-100 Unità di misura: 100 MCG Imballaggio: Vial 360,00 CHF 360.0 CHF Tempo di consegna attuale su richiesta	Paxillin is one of the key components of integrin signaling. Tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization. Paxillin is phosphorylated by another focal adhesion component, focal adhesion Numero articolo: BIOV3448-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	Bcl-6 encodes a protein of 706 amino acids with a predicted molecular weight of 79 kDa. The Bcl-6 protein has homology with zinc fin ger transcription factors. However, little is known about its functions. Numero articolo: BIOV3408-100 Unità di misura: 100 MCG Imballaggio: Vial 354,00 CHF 354.0 CHF Tempo di consegna attuale su richiesta	Members of the Bcl-2 family of proteins interact to regulate programmed cell death, or apoptosis. Various homodimers and heterodimer s formed by proteins in this family can either promote or inhibit apoptosis. Numero articolo: BIOV3176-100 Unità di misura: 100 MCG Imballaggio: Vial 360,00 CHF 360.0 CHF Tempo di consegna attuale su richiesta
PDK1 (Phosphoinositide-dependent protein kinase 1) plays an important role in cell signaling pathways and is involved in regulation of a wide variety of processes, including cell proliferation, differentiation and apoptosis. Numero articolo: BIOV3449-100 Unità di misura: 100 MCG Imballaggio: Vial 322,00 CHF 322.0 CHF Tempo di consegna attuale su richiesta	The synaptotagmins are integral membrane proteins of synaptic vesicles thoμght to serve as Ca (2+) sensors in the process of vesicul ar trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter Numero articolo: BIOV3177-100 Unità di misura: 100 MCG Imballaggio: Vial 335,00 CHF 335.0 CHF Tempo di consegna attuale su richiesta	p53DINP1 (p53-dependent damage-inducible nuclear protein 1) encodes two proteins termed p53DINP1-α (27 kDa) and p53DINP1-β (18 kDa). p53DINP1 may regulate p53-dependent apoptosis throμgh phosphorylation at Ser46 and induction of p53AIP1. p5 Numero articolo: BIOV3340-100 Unità di misura: 100 MCG Imballaggio: Vial 322,00 CHF 322.0 CHF Tempo di consegna attuale su richiesta	Caspase-9 is one of the most important caspases among the caspase family members. Upon induction of apoptosis, cytochrome c released from mitochondria associates with procaspase-9/Apaf-1. Numero articolo: BIOV3409-100 Unità di misura: 100 MCG Imballaggio: Vial 309,00 CHF 309.0 CHF Tempo di consegna attuale su richiesta

VWR / Merck Prodotti chimici