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Bad is a member of the Bcl-2 family protein that selectively dimerize with Bcl-xL and Bcl-2 resulting in cell death. Survival factor s such as IL-3 can inhibit the apoptotic activity of Bad by activating intracellular signaling pathways that Item Number: BIOV3269-100 Unit of Measure: 100 MCG Packaging: Vial 410.00 CHF 410.0 CHF Current delivery time on request	Transcription factor CREB binds the cAMP response element (CRE) and activates transcription in response to a variety of extracellula r signals including neurotransmitters, hormones, membrane depolarization, and growth or neurotrophic factors Item Number: BIOV3360R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Histone-lysine N- methyltransferase SETD3 has a function as methylation of Lys36 of histone H3 which represents a specific tag for e pigenetic transcriptional activation. It is highly expressed in muscular tissues. Item Number: BIOV3197-200 Unit of Measure: 200 MCG Packaging: Vial 347.00 CHF 347.0 CHF Current delivery time on request	Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. This gene encod es hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose- Item Number: BIOV3198-100 Unit of Measure: 100 MCG Packaging: Vial 360.00 CHF 360.0 CHF Current delivery time on request
Tumor Necrosis Factor-alpha (TNF-α) is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and cer tain other target cells. Rat TNF-α is a 17 kDa protein containing 157 amino acid residues. Item Number: BIOV3054-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control , DNA replication and chromatin organization. Item Number: BIOV3267-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Arginine methylation is an important protein modification catalyzed by arginine methyltransferase such as PRMT7. PRMT7 has two methy ltransferase domains each containing a putative AdoMet binding motif. Item Number: BIOV3059-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. Item Number: BIOV3199-100 Unit of Measure: 100 MCG Packaging: Vial 347.00 CHF 347.0 CHF Current delivery time on request
Cell adhesion molecules (CAMs) are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and are thoμght to play an important role in embryogenesis and development. BLCAM α and BLCAM β are p Item Number: BIOV3363-100 Unit of Measure: 100 MCG Packaging: Vial 322.00 CHF 322.0 CHF Current delivery time on request	Proinflammatory cytokine tumor necrosis factorα (TNF-α) contributes to a variety of inflammatory responses and programmed cell death . Item Number: BIOV3201-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Apoptosis can be induced by certain cytokines including TNF and Fas Ligand of the TNF super-family throμgh their death domain (DD) c ontaining receptors, TNFR1 and Fas. Item Number: BIOV3061R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	MAK10 protein regulates the proliferation of smooth muscle cells. The mammalian homologue of yeast MAK10, also known as EGAP, is one subunit of a novel N-terminal acetyltransferase (NAT) that is highly conserved among vertebrate species. Item Number: BIOV3134-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
RIP (Receptor Interacting Protein) is a 74 kDa Ser/Thr kinase which interacts with CD95 (Fas/Apo1) receptor and the tumor necrosis f actor receptor (TNFR1). It is a cell death domain adapter protein which can bind to the adapter proteins TRA Item Number: BIOV3279-100 Unit of Measure: 100 MCG Packaging: Vial 322.00 CHF 322.0 CHF Current delivery time on request	Caspase-7 is a 34 kDa protein consisting of two subunits and a short prodomain. The procaspase-7 can be activated by cleavage by ups tream caspases to form active caspase-7 in apoptosis. Item Number: BIOV3135-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	The MBD family of proteins includes MeCP2, MBD1, MBD2, MBD3 and MBD4. MBD1 (methyl-CpG binding domain protein 1) binds to methylated CpG sites and represses gene transcription. Item Number: BIOV3281-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	This antibody reacts with the Stage-specific embryonic antigen-3 (SSEA-3). The epitope is expressed on the surface of human teratoca rcinoma stem cells , embryonic carcinoma (EC) cells, human embryonic germ(EG) cells and human embryonic stem Item Number: BIOV3065-25 Unit of Measure: 25 MCG Packaging: Vial 272.00 CHF 272.0 CHF Current delivery time on request
Nestin may play a role in the trafficking and distribution of IF proteins and potentially other cellular factors to daμghter cells d uring progenitor cell division (By similarity). Item Number: BIOV3208-100 Unit of Measure: 100 MCG Packaging: Vial 360.00 CHF 360.0 CHF Current delivery time on request	Cathepsin F is a cysteine protease that plays a role in invariant chain processing and major histocompatibility complex class II pep tide loading by microphages. Cathepsin F has the substrate specificity similar to that of cathepsins L and S Item Number: BIOV3371-100 Unit of Measure: 100 4G Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Deoxyribonuclease I (DNase I) is a Ca2+ and Mg2+ dependent endonuclease. DNase I is synthesized in the pancreas and stored in zymoge n granules. It has been used to reduce the viscosity of cystic fibrosis sputum. Item Number: BIOV3214-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	MKK3 is a protein kinase that phosphorylates the p38 MAPK. Phosphorylation by MKK3 occurs on threonine and tyrosine residues and inc reases the activity of p38 to stimulate transcription factors ATF2 and Elk-1. MKK3, together with MKK6, serv Item Number: BIOV3285-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request

VWR / Merck Chemicals