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Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in pa ired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheim Item Number: BIOV3453-100 Unit of Measure: 100 4G Packaging: Vial 455.00 CHF 455.0 CHF Current delivery time on request	The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix compon ents, including collagen, gelatin, fibronectin, laminin and proteoglycan. Item Number: BIOV3533-100 Unit of Measure: 100 MCG Packaging: Vial 398.00 CHF 398.0 CHF Current delivery time on request	Chemokines play an important role in inflammation and are critical for the recruitment of effector immune cells to sites of infectio n. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine rece Item Number: BIOV3414-100 Unit of Measure: 100 MCG Packaging: Vial 354.00 CHF 354.0 CHF Current delivery time on request	SOD (Superoxide Dismutase) is a well characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals Item Number: BIOV3458-100 Unit of Measure: 100 MCG Packaging: Vial 322.00 CHF 322.0 CHF Current delivery time on request
IkB-alpha protein is a NF-kB inhibitory protein. It binds NF-kB and retains the complex in the cytoplasm, thereby preventing it from entering into nucleus and functioning as a transcription factor. Upon receiving a variety of signals, IkB-a Item Number: BIOV3252-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase that is closely related to Akt. SGK is rapidly induced in response to a variety of stimuli, including serum, hormones, and osmotic shock, etc. Item Number: BIOV3459-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	ACAA2 (acetylcoenzyme A acyltransferase 2), is member of the thiolase family of enzymes and is involved in lipid metabolism. ACAA2 i s localized in the mitochondria. ACCA2 catalyzes the last conversion step of acetyl-CoA to 3-oxoacyl-CoA, in Item Number: BIOV3538-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Che mokines activate leukocytes by binding to G protein coupled receptors. Item Number: BIOV3419-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
Cytochrome c (m.w. 12,500) is an electron transport protein from mitochondria. It is released from mitochondria to cytoplasm during the early stages of apoptosis, prior to caspase activation, DNA fragmentation, and loss of membrane potentia Item Number: BIOV3352-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad), have been implicated as downstream effectors of T GFβ/BMP signaling. Smad1, Smad5, and Smad8 are effectors of BMP2 and BMP4 function Item Number: BIOV3461-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Che mokines activate leukocytes by binding to G protein coupled receptors. Item Number: BIOV3416R-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cat hepsins B, L, H, K, S, and O. The aspartyl protease class is composed of cathepsins D and E. Item Number: BIOV3412-100 Unit of Measure: 100 MCG Packaging: Vial 373.00 CHF 373.0 CHF Current delivery time on request
Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad), have been implicated as downstream effectors of T GFβ/BMP signaling. Smad1, Smad5, and Smad8 are effectors of BMP2 and BMP4 function Item Number: BIOV3464-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Gαi2 is a 40-41 kDa alpha-subunit of heterotrimeric protein that shares sequence homology with Gαi3 and Gαi1. All these G proteins c an be ADP-ribosylated at the carboxy terminal Cys of the CAAX sequence, interfering with receptor coupling. Item Number: BIOV3249-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	It has been proposed that high density lipoproteins (HDLs) function jointly with lecithin:cholesterol acyltransferase and CETP to fa cilitate cholesterol transport from tissues to the liver. CETP is responsible for neutral lipid transfer act Item Number: BIOV3413-100 Unit of Measure: 100 MCG Packaging: Vial 354.00 CHF 354.0 CHF Current delivery time on request	Cytochrome c (m.w. 12,500) is an electron transport protein from mitochondria. It is released from mitochondria to cytoplasm during the early stages of apoptosis, prior to caspase activation, DNA fragmentation, and loss of membrane potentia Item Number: BIOV3353-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request
Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad), have been implicated as downstream effectors of T GFβ/BMP signaling. Smad1, Smad5, and Smad8 are effectors of BMP2 and BMP4 function Item Number: BIOV3465-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	GADD153 has been described as a growth arrest and DNA damage-inducible gene that encodes a C/EBP-related nuclear protein. Expression of GADD153 is induced by a variety of cellular stresses Item Number: BIOV3421-100 Unit of Measure: 100 MCG Packaging: Vial 335.00 CHF 335.0 CHF Current delivery time on request	Syntaxins were originally thoμght to be docking proteins, but have more recently been categorized as anchoring proteins that anchor themselves to the cytoplasmic surfaces of cellular membranes. Syntaxins have been shown to bind to various p Item Number: BIOV3541-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request	Caspase-6 is one of the major executioner caspases functioning in cellular apoptotic processes. Similar as other caspases, caspase-6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Item Number: BIOV3256-100 Unit of Measure: 100 MCG Packaging: Vial 309.00 CHF 309.0 CHF Current delivery time on request

VWR / Merck Chemicals